Name: 4 Ingredient Chicken Pasta Casserole
Prep time: 10 min
Cook time: 35 min
Total time: 45 min
Yield: 6 servings
Cuisine: American
Ingredients: 3 cups cooked chicken, shredded or diced; 12 oz uncooked penne or rotini pasta; 1 (15 oz) jar Alfredo sauce; 2 cups shredded mozzarella cheese, divided

Get ready-you're about to fall for the absolute easiest, cheesiest chicken pasta bake around! This 4 Ingredient Chicken Pasta Casserole is a weeknight hero, loaded with juicy chicken, tender pasta, and creamy, bubbling cheese in every comforting bite.

I love how the simple flavors come together to create something that feels totally homemade and nostalgic, without hours in the kitchen. Plus, it all bakes in one dish-less mess, more yum!

Perfect for busy families, picky eaters, or anyone craving good old-fashioned comfort. This is the casserole I turn to when I want dinner to be fast, satisfying, and guaranteed to get rave reviews at the table.

Golden, cheesy casserole fresh from the oven

Why You'll Love This Recipe

So simple-just 4 staple ingredients and 45 minutes from start to finish!
Total comfort food: cheesy, creamy, and ultra-satisfying.
One pan, minimal cleanup, and family-approved.
Versatile-easy to adapt with pantry swaps or extras you enjoy.

Key Ingredients for 4 Ingredient Chicken Pasta Casserole

See recipe card below for full list of measurements, ingredients, and instructions.

Cooked Chicken

Chicken is the heart of this casserole, making it hearty and protein-packed. Use rotisserie chicken for max convenience or any pre-cooked chicken you have on hand. Shred or dice it so every bite gets a bit of chicken. Leftover grilled or baked chicken works perfectly, and you can even swap in turkey if you're using up holiday extras.

Pasta

Pasta brings the classic comfort here, soaking up all that creamy, cheesy goodness. Short cuts like penne, rotini, or elbow macaroni work best-just cook them al dente so they hold up while baking. Whole wheat or gluten-free pastas are great swaps without changing the overall dish.

Alfredo Sauce

Store-bought Alfredo sauce brings all the creaminess with ZERO fuss. Look for a jarred sauce with real cheese for maximum flavor, or feel free to use homemade Alfredo if you're feeling fancy. Want a lighter version? Try a reduced-fat Alfredo or even a creamy garlic pasta sauce.

Shredded Mozzarella Cheese

Melty mozzarella gives you that irresistible cheesy topping and classic casserole stretch. Pre-shredded cheese keeps things extra easy, or try an Italian blend for a boost of flavor. For extra richness, you could swap in sharp cheddar or Monterey Jack-let your taste buds decide!

4 Ingredient Chicken Pasta Casserole cooking process

Instructions for 4 Ingredient Chicken Pasta Casserole

See recipe card below for full list of measurements, ingredients, and instructions.

Cook the Pasta

First, bring a large pot of salted water to a boil. Add your pasta and cook according to package directions until just al dente (usually about 8-9 minutes). Drain and set aside-it'll finish cooking in the oven, so don't overcook.

Mix the Casserole

In a large bowl, combine the cooked chicken, drained pasta, Alfredo sauce, and 1 ½ cups of the shredded mozzarella. Stir everything together so every piece is coated in the creamy sauce and cheese.

Assemble in Baking Dish

Lightly grease a 9x13-inch casserole dish. Pour the chicken and pasta mixture into the dish and spread evenly. Sprinkle the remaining ½ cup of mozzarella on top for that golden, bubbly finish.

Bake

Bake in a preheated 350°F (175°C) oven for 25-30 minutes, or until the cheese is thoroughly melted and the casserole is bubbling around the edges. For extra golden top, broil on high for 2-3 minutes-just watch carefully so it doesn't burn.

Recipe Variations

Add Some Veggies

Toss in a cup of frozen peas, broccoli florets, or spinach before baking for extra color and nutrients. They'll blend right in with the sauce and make it a complete meal.

Spice It Up

If your crew likes a little heat, stir in a pinch of red pepper flakes, black pepper, or a handful of sliced jalapeños. Smoked paprika or Italian seasoning can give even more depth to the flavor.

Make It Gluten Free

Just swap in your favorite gluten-free pasta for an easy gluten-free version. Double check your Alfredo sauce as well-most are gluten-free but a quick label check is always wise.

Dairy-Free Option

For a dairy-free twist, use a plant-based Alfredo sauce and dairy-free mozzarella shreds. The result is just as creamy and comforting!

Swap the Sauce

Feel free to substitute the Alfredo with marinara or tomato basil sauce for a red-sauce variation. This simple swap gives you a whole new flavor profile.

Serving Suggestions

This casserole is hearty on its own, but a crisp green salad or simple garlic bread makes it a truly satisfying meal. Sprinkle chopped parsley or fresh basil on top for a pop of freshness, and try a side of steamed broccoli or roasted veggies for added nutrition.

Storage and Reheating

Store leftover casserole in an airtight container in the refrigerator for up to 4 days. To reheat, scoop individual servings into a microwave-safe bowl and heat in 1-minute intervals until hot. For larger portions, cover with foil and bake at 350°F for 15-20 minutes. This dish also freezes well-wrap tightly and freeze for up to 2 months. Thaw overnight in the fridge before reheating as above.

Frequently Asked Questions About 4 Ingredient Chicken Pasta Casserole (FAQ)

Q: Can I use uncooked chicken in this casserole?

A: For food safety and the best texture, start with fully cooked chicken. If you only have raw chicken, cook it beforehand by baking, poaching, or sautéing.

Q: What kind of pasta works best?

A: Short-cut pastas like penne, rotini, fusilli, or elbows hold up well and mix easily with the sauce. Avoid long strands like spaghetti for this one.

Q: How can I make this ahead of time?

A: Assemble the casserole up to a day in advance, cover, and refrigerate. When ready to bake, add a few extra minutes to the bake time since it will be starting cold.

This is the kind of recipe that makes busy weeknights a breeze and still has everyone asking for seconds! I hope you love how easy and delicious this 4 Ingredient Chicken Pasta Casserole is. Don't forget to let me know how yours turned out-leave a comment and rating below!

★★★★★ 4.80 from 197 ratings